Gene Expression Literature Summary

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Dlx5  distal-less homeobox 5
Results	Reference
1	J:56557 Acampora D, Merlo GR, Paleari L, Zerega B, Postiglione MP, Mantero S, Bober E, Barbieri O, Simeone A, Levi G, Craniofacial, vestibular and bone defects in mice lacking the Distal-less-related gene Dlx5. Development. 1999 Sep;126(17):3795-809
1*	J:184001 Ahmed M, Xu J, Xu PX, EYA1 and SIX1 drive the neuronal developmental program in cooperation with the SWI/SNF chromatin-remodeling complex and SOX2 in the mammalian inner ear. Development. 2012 Jun;139(11):1965-77
1*	J:87221 Alvarez Y, Alonso MT, Vendrell V, Zelarayan LC, Chamero P, Theil T, Bosl MR, Kato S, Maconochie M, Riethmacher D, Schimmang T, Requirements for FGF3 and FGF10 during inner ear formation. Development. 2003 Dec;130(25):6329-38
1	J:173619 Barron F, Woods C, Kuhn K, Bishop J, Howard MJ, Clouthier DE, Downregulation of Dlx5 and Dlx6 expression by Hand2 is essential for initiation of tongue morphogenesis. Development. 2011 Jun;138(11):2249-59
1	J:228880 Birol O, Ohyama T, Edlund RK, Drakou K, Georgiades P, Groves AK, The mouse Foxi3 transcription factor is necessary for the development of posterior placodes. Dev Biol. 2016 Jan 1;409(1):139-51
1	J:199615 Cases O, Perea-Gomez A, Aguiar DP, Nykjaer A, Amsellem S, Chandellier J, Umbhauer M, Cereghini S, Madsen M, Collignon J, Verroust P, Riou JF, Creuzet SE, Kozyraki R, Cubilin, a high affinity receptor for fibroblast growth factor 8, is required for cell survival in the developing vertebrate head. J Biol Chem. 2013 Jun 7;288(23):16655-70
1	J:171520 Compagnucci C, Fish JL, Schwark M, Tarabykin V, Depew MJ, Pax6 regulates craniofacial form through its control of an essential cephalic ectodermal patterning center. Genesis. 2011 Apr;49(4):307-25
1	J:152832 Dupe V, Pellerin I, Retinoic acid receptors exhibit cell-autonomous functions in cranial neural crest cells. Dev Dyn. 2009 Sep 23;238(10):2701-2711
1*	J:56579 Ferguson CA, Tucker AS, Sharpe PT, Temporospatial cell interactions regulating mandibular and maxillary arch patterning. Development. 2000 Jan;127(2):403-12
1*	J:328711 Fernandez-Guerrero M, Zdral S, Castilla-Ibeas A, Lopez-Delisle L, Duboule D, Ros MA, Time-sequenced transcriptomes of developing distal mouse limb buds: A comparative tissue layer analysis. Dev Dyn. 2022 Sep;251(9):1550-1575
1	J:191738 Harel I, Maezawa Y, Avraham R, Rinon A, Ma HY, Cross JW, Leviatan N, Hegesh J, Roy A, Jacob-Hirsch J, Rechavi G, Carvajal J, Tole S, Kioussi C, Quaggin S, Tzahor E, Pharyngeal mesoderm regulatory network controls cardiac and head muscle morphogenesis. Proc Natl Acad Sci U S A. 2012 Nov 13;109(46):18839-44
1	J:128377 Hatch EP, Noyes CA, Wang X, Wright TJ, Mansour SL, Fgf3 is required for dorsal patterning and morphogenesis of the inner ear epithelium. Development. 2007 Oct;134(20):3615-25
1	J:102844 Ishii M, Han J, Yen HY, Sucov HM, Chai Y, Maxson RE Jr, Combined deficiencies of Msx1 and Msx2 cause impaired patterning and survival of the cranial neural crest. Development. 2005 Nov;132(22):4937-50
1*	J:254776 Johnson KR, Gagnon LH, Tian C, Longo-Guess CM, Low BE, Wiles MV, Kiernan AE, Deletion of a Long-Range Dlx5 Enhancer Disrupts Inner Ear Development in Mice. Genetics. 2018 Mar;208(3):1165-1179
1	J:333327 Kurihara Y, Ekimoto T, Gordon CT, Uchijima Y, Sugiyama R, Kitazawa T, Iwase A, Kotani R, Asai R, Pingault V, Ikeguchi M, Amiel J, Kurihara H, Mandibulofacial dysostosis with alopecia results from ETAR gain-of-function mutations via allosteric effects on ligand binding. J Clin Invest. 2023 Feb 15;133(4)
1	J:134688 Lewis SL, Khoo PL, De Young RA, Steiner K, Wilcock C, Mukhopadhyay M, Westphal H, Jamieson RV, Robb L, Tam PP, Dkk1 and Wnt3 interact to control head morphogenesis in the mouse. Development. 2008 May;135(10):1791-801
1*	J:119031 Lillevali K, Haugas M, Matilainen T, Pussinen C, Karis A, Salminen M, Gata3 is required for early morphogenesis and Fgf10 expression during otic development. Mech Dev. 2006 Jun;123(6):415-29
1	J:135784 Lo Iacono N, Mantero S, Chiarelli A, Garcia E, Mills AA, Morasso MI, Costanzo A, Levi G, Guerrini L, Merlo GR, Regulation of Dlx5 and Dlx6 gene expression by p63 is involved in EEC and SHFM congenital limb defects. Development. 2008 Apr;135(7):1377-88
1	J:214961 Milgrom-Hoffman M, Michailovici I, Ferrara N, Zelzer E, Tzahor E, Endothelial cells regulate neural crest and second heart field morphogenesis. Biol Open. 2014;3(8):679-88
1*	J:273047 Narboux-Neme N, Ekker M, Levi G, Heude E, Posterior axis formation requires Dlx5/Dlx6 expression at the neural plate border. PLoS One. 2019;14(3):e0214063
1*	J:105983 Ohyama T, Mohamed OA, Taketo MM, Dufort D, Groves AK, Wnt signals mediate a fate decision between otic placode and epidermis. Development. 2006 Mar;133(5):865-75
1*	J:104488 Ozaki H, Nakamura K, Funahashi J, Ikeda K, Yamada G, Tokano H, Okamura HO, Kitamura K, Muto S, Kotaki H, Sudo K, Horai R, Iwakura Y, Kawakami K, Six1 controls patterning of the mouse otic vesicle. Development. 2004 Feb;131(3):551-62
1*	J:90465 Ozeki H, Kurihara Y, Tonami K, Watatani S, Kurihara H, Endothelin-1 regulates the dorsoventral branchial arch patterning in mice. Mech Dev. 2004 Apr;121(4):387-95
1	J:199449 Paschaki M, Cammas L, Muta Y, Matsuoka Y, Mak SS, Rataj-Baniowska M, Fraulob V, Dolle P, Ladher RK, Retinoic acid regulates olfactory progenitor cell fate and differentiation. Neural Dev. 2013;8:13
1*	J:40427 Qiu M, Bulfone A, Ghattas I, Meneses JJ, Christensen L, Sharpe PT, Presley R, Pedersen RA, Rubenstein JL, Role of the Dlx homeobox genes in proximodistal patterning of the branchial arches: mutations of Dlx-1, Dlx-2, and Dlx-1 and -2 alter morphogenesis of proximal skeletal and soft tissue structures derived from the first and second arches. Dev Biol. 1997 May 15;185(2):165-84
1	J:64994 Quint E, Zerucha T, Ekker M, Differential expression of orthologous Dlx genes in zebrafish and mice: implications for the evolution of the Dlx homeobox gene family. J Exp Zool. 2000 Oct 15;288(3):235-41
1	J:177362 Rhinn M, Schuhbaur B, Niederreither K, Dolle P, Involvement of retinol dehydrogenase 10 in embryonic patterning and rescue of its loss of function by maternal retinaldehyde treatment. Proc Natl Acad Sci U S A. 2011 Oct 4;108(40):16687-92
1	J:99408 Riccomagno MM, Takada S, Epstein DJ, Wnt-dependent regulation of inner ear morphogenesis is balanced by the opposing and supporting roles of Shh. Genes Dev. 2005 Jul 1;19(13):1612-23
1	J:149166 Ruest LB, Clouthier DE, Elucidating timing and function of endothelin-A receptor signaling during craniofacial development using neural crest cell-specific gene deletion and receptor antagonism. Dev Biol. 2009 Apr 1;328(1):94-108
1	J:131382 Sato T, Kawamura Y, Asai R, Amano T, Uchijima Y, Dettlaff-Swiercz DA, Offermanns S, Kurihara Y, Kurihara H, Recombinase-mediated cassette exchange reveals the selective use of Gq/G11-dependent and -independent endothelin 1/endothelin type A receptor signaling in pharyngeal arch development. Development. 2008 Feb;135(4):755-65
1	J:128571 Selever J, Liu W, Lu MF, Behringer RR, Martin JF, Bmp4 in limb bud mesoderm regulates digit pattern by controlling AER development. Dev Biol. 2004 Dec 15;276(2):268-79
1*	J:209112 Shimizu H, Kubo A, Uchibe K, Hashimoto M, Yokoyama S, Takada S, Mitsuoka K, Asahara H, The AERO system: a 3D-like approach for recording gene expression patterns in the whole mouse embryo. PLoS One. 2013;8(10):e75754
1	J:300591 Shimizu M, Narboux-Neme N, Gitton Y, de Lombares C, Fontaine A, Alfama G, Kitazawa T, Kawamura Y, Heude E, Marshall L, Higashiyama H, Wada Y, Kurihara Y, Kurihara H, Levi G, Probing the origin of matching functional jaws: roles of Dlx5/6 in cranial neural crest cells. Sci Rep. 2018 Oct 8;8(1):14975
1*	J:190564 Tavares AL, Garcia EL, Kuhn K, Woods CM, Williams T, Clouthier DE, Ectodermal-derived Endothelin1 is required for patterning the distal and intermediate domains of the mouse mandibular arch. Dev Biol. 2012 Nov 1;371(1):47-56
1	J:81179 Trokovic N, Trokovic R, Mai P, Partanen J, Fgfr1 regulates patterning of the pharyngeal region. Genes Dev. 2003 Jan 1;17(1):141-53
1	J:58999 Trumpp A, Depew MJ, Rubenstein JL, Bishop JM, Martin GR, Cre-mediated gene inactivation demonstrates that FGF8 is required for cell survival and patterning of the first branchial arch. Genes Dev. 1999 Dec 1;13(23):3136-48
1	J:311848 Wang YC, Juan HC, Wong YH, Kuo WC, Lu YL, Lin SF, Lu CJ, Fann MJ, Protogenin prevents premature apoptosis of rostral cephalic neural crest cells by activating the alpha5beta1-integrin. Cell Death Dis. 2013 Jun 6;4:e651
1*	J:83659 Wright TJ, Mansour SL, Fgf3 and Fgf10 are required for mouse otic placode induction. Development. 2003 Aug;130(15):3379-90
1*	J:156017 Yokoyama S, Ito Y, Ueno-Kudoh H, Shimizu H, Uchibe K, Albini S, Mitsuoka K, Miyaki S, Kiso M, Nagai A, Hikata T, Osada T, Fukuda N, Yamashita S, Harada D, Mezzano V, Kasai M, Puri PL, Hayashizaki Y, Okado H, Hashimoto M, Asahara H, A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Dev Cell. 2009 Dec;17(6):836-48
1	J:124118 Zelarayan LC, Vendrell V, Alvarez Y, Dominguez-Frutos E, Theil T, Alonso MT, Maconochie M, Schimmang T, Differential requirements for FGF3, FGF8 and FGF10 during inner ear development. Dev Biol. 2007 Aug 15;308(2):379-91
1	J:39628 Zhang H, Hu G, Wang H, Sciavolino P, Iler N, Shen MM, Abate-Shen C, Heterodimerization of Msx and Dlx homeoproteins results in functional antagonism. Mol Cell Biol. 1997 May;17(5):2920-32
1	J:254919 Zhang H, Wang L, Wong EYM, Tsang SL, Xu PX, Lendahl U, Sham MH, An Eya1-Notch axis specifies bipotential epibranchial differentiation in mammalian craniofacial morphogenesis. Elife. 2017 Nov 15;6:e30126